Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo

• Main Authors: Shunsuke Wada (Author), Satoshi Obika (Author), Masa-Aki Shibata (Author), Tsuyoshi Yamamoto (Author), Moeka Nakatani (Author), Tetsuji Yamaoka (Author), Hidetaka Torigoe (Author), Mariko Harada-Shiba (Author)
• 格式: 圖書
• 出版: Elsevier, 2012-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Recent advances in RNA interference (RNAi)-based drug development have partially allowed systemic administration of these agents in vivo with promising therapeutic effects. However, before chemically modified small-interfering RNAs (siRNAs) can be applied clinically, their in vivo effects should be...