Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo
Recent advances in RNA interference (RNAi)-based drug development have partially allowed systemic administration of these agents in vivo with promising therapeutic effects. However, before chemically modified small-interfering RNAs (siRNAs) can be applied clinically, their in vivo effects should be...
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Główni autorzy: | Shunsuke Wada (Autor), Satoshi Obika (Autor), Masa-Aki Shibata (Autor), Tsuyoshi Yamamoto (Autor), Moeka Nakatani (Autor), Tetsuji Yamaoka (Autor), Hidetaka Torigoe (Autor), Mariko Harada-Shiba (Autor) |
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Format: | Książka |
Wydane: |
Elsevier,
2012-01-01T00:00:00Z.
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