Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia-reperfusion damage

• Main Authors: Francesca M. Alves (Author), Kai Kysenius (Author), Marissa K. Caldow (Author), Justin P. Hardee (Author), Peter J. Crouch (Author), Scott Ayton (Author), Ashley I. Bush (Author), Gordon S. Lynch (Author), René Koopman (Author)
• Format: Book
• Published: Wiley, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few studies have investigated the role of iron, which is elevated during ageing, in age‐related muscle wasting and blunted repair after injury. We hypothesized that iro...