Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

• Main Authors: Kristine Rossbach (Author), Katharina Wahle (Author), Gustav Bruer (Author), Ralph Brehm (Author), Marion Langeheine (Author), Kristina Rode (Author), Katrin Schaper-Gerhardt (Author), Ralf Gutzmer (Author), Thomas Werfel (Author), Manfred Kietzmann (Author), Wolfgang Bäumer (Author)
• Format: Book
• Published: Medical Journals Sweden, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1-4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of t...