MicroRNA-10a/b inhibit TGF-β/Smad-induced renal fibrosis by targeting TGF-β receptor 1 in diabetic kidney disease

• Main Authors: Jinxiang Li (Author), Shuling Yue (Author), Jingwen Fang (Author), Junling Zeng (Author), Siqi Chen (Author), Jianwei Tian (Author), Sheng Nie (Author), Xiaoting Liu (Author), Hanying Ding (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TGF-β/Smad signaling plays a vital role in the development of fibrosis in diabetic kidney disease (DKD). However, remedies targeting key elements in TGF-β/Smad signaling are lacking. Here, we found that TGF-β receptor 1 (TGFBR1), a key protein in TGF-β/Smad signaling, was upregulated in kidney from...