Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties

• Main Authors: Andrea Mariela Araya-Sibaja (Author), Carlos Eduardo Maduro de Campos (Author), Cinira Fandaruff (Author), José Roberto Vega-Baudrit (Author), Teodolito Guillén-Girón (Author), Mirtha Navarro-Hoyos (Author), Silvia Lucía Cuffini (Author)
• Format: Book
• Published: Elsevier, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2...