Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties

• Autori principali: Andrea Mariela Araya-Sibaja (Autore), Carlos Eduardo Maduro de Campos (Autore), Cinira Fandaruff (Autore), José Roberto Vega-Baudrit (Autore), Teodolito Guillén-Girón (Autore), Mirtha Navarro-Hoyos (Autore), Silvia Lucía Cuffini (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2019-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2...