Quantitative Immunohistochemistry to Measure Regional Expression of Nurr1 in the Brain and the Effect of the Nurr1 Heterozygous Genotype

• Hauptverfasser: Evangel Kummari (Verfasst von), Shirley X. Guo-Ross (Verfasst von), Heath S. Partington (Verfasst von), Jennifer Makenzie Nutter (Verfasst von), Jeffrey B. Eells (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Schlagworte: article
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The transcription factor Nurr1 is a member of the steroid hormone nuclear receptor superfamily. Ablation of Nurr1 expression arrests mesencephalic dopamine neuron differentiation while attenuation of Nurr1 in the subiculum and hippocampus impairs learning and memory. Additionally, reduced Nurr1 expr...