Evaluation of a Sequential Antibiotic Treatment Regimen of Ampicillin, Ciprofloxacin and Fosfomycin against <i>Escherichia coli</i> CFT073 in the Hollow Fiber Infection Model Compared with Simultaneous Combination Treatment

• Main Authors: Ashok Krishna (Author), Tesfalem Zere (Author), Sabyasachy Mistry (Author), Omnia Ismaiel (Author), Heather Stone (Author), Leonard V. Sacks (Author), James L. Weaver (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Employ the hollow fiber infection model (HFIM) to study sequential antibiotic administration (ampicillin, ciprofloxacin and fosfomycin) using human pharmacokinetic profiles to measure changes in the rate of antibiotic resistance development and compare this to simultaneous combination the...