Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects

• Main Authors: P.S. Kheoane (Author), K.C. Mokhetho (Author), S. Mokhele (Author), K.C. Mbara (Author), C.M. Leonard (Author), T.H. Gadaga (Author), C. Tarirai (Author)
• Format: Book
• Published: Elsevier, 2025-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Wild edible plants (WEPs) including herbs provide staple foods as well as income for local communities on the African continent. However, these commonly used plant materials interact with orthodox or conventional drugs through both p-glycoprotein (P-gp) and cytochrome P450 enzymes inhibi...