Effects of Long-Term Hepatic Ischemia-Reperfusion Injury on the Function of P-glycoprotein in vivo in Rats

• Main Authors: Camilla A Thorling (Author), Michael S Roberts (Author), Xin Liu (Author), Linda M Fletcher (Author), Darrell Crawford (Author), Frank J Burczynski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Ischemia-reperfusion injury is a common complication in liver surgery with oxidative stress related graft failure as a potential complication. The oxidative stress could affect hepatic drug transporters such as P-glycoprotein, which is crucial in the hepatic clearance of certain immunosuppr...