Ultrasound Microbubble-Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane

• Main Authors: Yi-Chun Lin (Author), Cheng-Ping Shih (Author), Hsin-Chien Chen (Author), Ying-Liang Chou (Author), Huey-Kang Sytwu (Author), Mei-Cho Fang (Author), Yuan-Yung Lin (Author), Chao-Yin Kuo (Author), Hsiao-Han Su (Author), Chia-Lien Hung (Author), Hang-Kang Chen (Author), Chih-Hung Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The application of ultrasound microbubbles (USMBs) enhances the permeability of the round window membrane (RWM) and improves drug delivery to the inner ear. In this study, we investigated the efficiency of USMB-aided delivery of chitosan-coated gold nanoparticles (CS-AuNPs) and the mechanism of USMB...