Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect

• Main Authors: Li Li (Author), Chang-Sheng Wu (Author), Guan-Mei Hou (Author), Ming-Zhe Dong (Author), Zhen-Bo Wang (Author), Yi Hou (Author), Heide Schatten (Author), Gui-Rong Zhang (Author), Qing-Yuan Sun (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown. Methods We generated a T2D mouse model by using high-fat-diet (HFD) and Streptozotocin (STZ) injection. We examined mtDNA mutations...