Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect
Abstract Background Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown. Methods We generated a T2D mouse model by using high-fat-diet (HFD) and Streptozotocin (STZ) injection. We examined mtDNA mutations...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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BMC,
2018-11-01T00:00:00Z.
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