Screening assay for inhibitors of a recombinant Streptococcus pneumoniae UDP-glucose pyrophosphorylase

• Main Authors: Agustín Zavala (Author), Verónica Kovacec (Author), Gustavo Levín (Author), Albertina Moglioni (Author), María Victoria Miranda (Author), Ernesto García (Author), Laura Bonofiglio (Author), Marta Mollerach (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The UDP-glucose pyrophosphorylase of Streptococcus pneumoniae (GalUSpn) is absolutely required for the biosynthesis of capsular polysaccharide, the sine qua non virulence factor of pneumococcus. Since the eukaryotic enzymes are completely unrelated to their prokaryotic counterparts, we propose that...