Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor

• Main Authors: David Porciani (Author), Giovanni Signore (Author), Laura Marchetti (Author), Paolo Mereghetti (Author), Riccardo Nifosì (Author), Fabio Beltram (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors. Here, we investigate the relationship between the folding...