CRISPR/Cas9-Mediated Genome Editing Corrects Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy

Muscle stem cells (MuSCs) hold great therapeutic potential for muscle genetic disorders, such as Duchenne muscular dystrophy (DMD). The CRISP/Cas9-based genome editing is a promising technology for correcting genetic alterations in mutant genes. In this study, we used fibrin-gel culture system to se...

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Main Authors: Pei Zhu (Author), Furen Wu (Author), Jeffrey Mosenson (Author), Hongmei Zhang (Author), Tong-Chuan He (Author), Wen-Shu Wu (Author)
Format: Book
Published: Elsevier, 2017-06-01T00:00:00Z.
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