Clinical Relevance of Novel Polymorphisms in the Dihydropyrimidine Dehydrogenase (<i>DPYD</i>) Gene in Patients with Severe Fluoropyrimidine Toxicity: A Spanish Case-Control Study

Clinical Relevance of Novel Polymorphisms in the Dihydropyrimidine Dehydrogenase (<i>DPYD</i>) Gene in Patients with Severe Fluoropyrimidine Toxicity: A Spanish Case-Control Study

Among cancer patients treated with fluoropyrimidines, 10-40% develop severe toxicity. Polymorphism of the dihydropyrimidine dehydrogenase (<i>DPYD</i>) gene may reduce DPD function, the main enzyme responsible for the metabolism of fluoropyrimidines. This leads to drug accumulation and t...

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Main Authors: Paula Soria-Chacartegui (Author), Gonzalo Villapalos-García (Author), Luis A. López-Fernández (Author), Marcos Navares-Gómez (Author), Gina Mejía-Abril (Author), Francisco Abad-Santos (Author), Pablo Zubiaur (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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