A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis

• Main Authors: Jingwen Zhang (Author), Guohua Yu (Author), Yanting Yang (Author), Yingjie Wang (Author), Mengqi Guo (Author), Qikun Yin (Author), Chunhong Yan (Author), Jingwei Tian (Author), Fenghua Fu (Author), Hongbo Wang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysfunction of p53 is observed in many malignant tumors, which is related to cancer susceptibility. In cervical cancer, p53 is primarily degradated through the complex of high-risk human papillomaviruses (HPV) oncoprotein E6 and E6-associated protein (E6AP) ubiquitin ligase. What is less clear is th...