hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

• Main Authors: Juliette Duchesne De Lamotte (Author), Sylvain Roqueviere (Author), Hélène Gautier (Author), Elsa Raban (Author), Céline Bouré (Author), Elena Fonfria (Author), Johannes Krupp (Author), Camille Nicoleau (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Botulinum neurotoxins (BoNTs) are zinc metalloproteases that block neurotransmitter release at the neuromuscular junction (NMJ). Their high affinity for motor neurons combined with a high potency have made them extremely effective drugs for the treatment of a variety of neurological diseases as well...