Electrospray-Based Microencapsulation of Epigallocatechin 3-Gallate for Local Delivery into the Intervertebral Disc

• Autori principali: Moira Loepfe (Autore), Anja Duss (Autore), Katerina-Alexandra Zafeiropoulou (Autore), Oddny Björgvinsdóttir (Autore), Matteo D'Este (Autore), David Eglin (Autore), Giuseppino Fortunato (Autore), Juergen Klasen (Autore), Stephen J. Ferguson (Autore), Karin Wuertz-Kozak (Autore), Olga Krupkova (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2019-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Locally delivered anti-inflammatory compounds can restore the homeostasis of the degenerated intervertebral disc (IVD). With beneficial effects on IVD cells, epigallocatechin 3-gallate (EGCG) is a promising therapeutic candidate. However, EGCG is prone to rapid degradation and/or depletion. Therefor...