Electrospray-Based Microencapsulation of Epigallocatechin 3-Gallate for Local Delivery into the Intervertebral Disc

• Main Authors: Moira Loepfe (Author), Anja Duss (Author), Katerina-Alexandra Zafeiropoulou (Author), Oddny Björgvinsdóttir (Author), Matteo D'Este (Author), David Eglin (Author), Giuseppino Fortunato (Author), Juergen Klasen (Author), Stephen J. Ferguson (Author), Karin Wuertz-Kozak (Author), Olga Krupkova (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Locally delivered anti-inflammatory compounds can restore the homeostasis of the degenerated intervertebral disc (IVD). With beneficial effects on IVD cells, epigallocatechin 3-gallate (EGCG) is a promising therapeutic candidate. However, EGCG is prone to rapid degradation and/or depletion. Therefor...