Generation of desminopathy in rats using CRISPR‐Cas9

Generation of desminopathy in rats using CRISPR‐Cas9

Abstract Background Desminopathy is a clinically heterogeneous muscle disease caused by over 60 different mutations in desmin. The most common mutation with a clinical phenotype in humans is an exchange of arginine to proline at position 350 of desmin leading to p.R350P. We created the first CRISPR‐...

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Main Authors: Henning T. Langer (Author), Agata A. Mossakowski (Author), Brandon J. Willis (Author), Kristin N. Grimsrud (Author), Joshua A. Wood (Author), Kevin C.K. Lloyd (Author), Hermann Zbinden‐Foncea (Author), Keith Baar (Author)
Format: Book
Published: Wiley, 2020-10-01T00:00:00Z.
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3rd Floor Main Library

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