Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

• Main Authors: Matthew Elcombe (Author), Ayesha Mathur (Author), Stephanie Wallace (Author), Jayne Wright (Author), Simon Plummer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In vivo treatment of rats with phenobarbital (PB) induces liver enzyme induction associated with hepatocyte hypertrophy. In the present study we used a novel microTMA technology coupled with artificial intelligence (AI) driven image analysis and proteomics analysis to test the hypothesis that PB tre...