Cover Image

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

Background and purpose: Fengshi Gutong capsule (FSGTC), a traditional herbal formula, has been used clinically in China for the treatment of arthritis. However, the mechanism underlying the therapeutic effects of FSGTC on osteoarthritis (OA) has not been elucidated. The present study investigated th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yao-Xin Gao (Author), Hao-Heng Yu (Author), Chuan He (Author), Ming Li (Author), Dan-Dan Guo (Author), Jun-Jiang Lian (Author), Hai-Jie Yang (Author), Mian Wang (Author), Lei Wang (Author), Zhi-Wei Feng (Author), Bin-Feng Cheng (Author)
Format:	Book
Published:	Frontiers Media S.A., 2018-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways
by: Yue Miao, et al.
Published: (2024)

Efficacy and safety of Gutong Patch compared with NSAIDs for knee osteoarthritis: A real-world multicenter, prospective cohort study in China
by: Yingjie Wang, et al.
Published: (2023)

Recombinant Human Endostatin Suppresses Mouse Osteoclast Formation by Inhibiting the NF-κB and MAPKs Signaling Pathways
by: Non eChen, et al.
Published: (2016)

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes
by: Feng Zhou, et al.
Published: (2019)

Phenethylferulate as a natural inhibitor of inflammation in LPS-stimulated RAW 264.7 macrophages: focus on NF-κB, Akt and MAPK signaling pathways
by: Zhongjie Yan, et al.
Published: (2023)

Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway
by: Jiameng Ding, et al.
Published: (2022)

NFκB and AP-1 Drive Human Myometrial IL8 Expression
by: Shirin Khanjani, et al.
Published: (2012)

Correspondence: Study Comparing Gutong Patch and NSAIDs in Treating Knee Osteoarthritis
by: Hung-Hsuan Wang, et al.
Published: (2024)

Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways
by: Xuantao Hu, et al.
Published: (2020)

α-Mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-κB and MAPK signaling
by: Wenkan Zhang, et al.
Published: (2022)

Anti-Inflammatory Effects of Aster incisus through the Inhibition of NF-κB, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages
by: Daniel Ngabire, et al.
Published: (2018)

Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/IκB/NF-κB Pathway on Human Umbilical Vein Endothelial Cells
by: Shaoyang Zhang, et al.
Published: (2020)

Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-κB and MAPK signaling pathways
by: Dingwei Cang, et al.
Published: (2021)

Morroniside Inhibits Inflammatory Bone Loss through the TRAF6-Mediated NF-κB/MAPK Signalling Pathway
by: Jirimutu Xiao, et al.
Published: (2023)

20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways
by: Chenhao Pan, et al.
Published: (2019)

Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
by: Huan Yang, et al.
Published: (2022)

Gut Microbiota-Derived PGF2α Fights against Radiation-Induced Lung Toxicity through the MAPK/NF-κB Pathway
by: Zhi-Yuan Chen, et al.
Published: (2021)

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways
by: Wei Wang, et al.
Published: (2020)

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
by: Zuoxing Wu, et al.
Published: (2022)

Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways
by: Mi Zhou, et al.
Published: (2024)

Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway
by: Ran Deng, et al.
Published: (2018)

Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways
by: Shuo-Lei Zheng, et al.
Published: (2024)

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
by: Minjun Yao, et al.
Published: (2022)

Anhuienoside C Ameliorates Collagen-Induced Arthritis through Inhibition of MAPK and NF-κB Signaling Pathways
by: Qing Liu, et al.
Published: (2017)

ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways
by: Xuejun Wang, et al.
Published: (2022)

Anemoside B4 ameliorates TNBS-induced colitis through S100A9/MAPK/NF-κB signaling pathway
by: Yong Zhang, et al.
Published: (2021)

Eucalyptus essential oils inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through reducing MAPK and NF-κB pathways
by: Chen-Lung Ho, et al.
Published: (2020)

Anti-inflammatory effect of gallic acid on HaCaT keratinocytes through the inhibition of MAPK-, NF-kB-, and Akt-dependent signaling pathways
by: Polly Ho-Ting Shiu, et al.
Published: (2023)

N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways
by: Li-Jun Huang, et al.
Published: (2022)

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
by: Rui Lu, et al.
Published: (2021)

Astragaloside IV Relieves Atherosclerosis and Hepatic Steatosis via MAPK/NF-κB Signaling Pathway in LDLR−/− Mice
by: Yifan Zhang, et al.
Published: (2022)

Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway
by: Xin Lv, et al.
Published: (2021)

Dusuqing granules (DSQ) suppress inflammation in Klebsiella pneumonia rat via NF-κB/MAPK signaling
by: Xue Mei, et al.
Published: (2017)

Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats
by: Fang Cheng, et al.
Published: (2019)

Unripe <i>Carica papaya</i> Protects Methylglyoxal-Invoked Endothelial Cell Inflammation and Apoptosis via the Suppression of Oxidative Stress and Akt/MAPK/NF-κB Signals
by: Wattanased Jarisarapurin, et al.
Published: (2021)

Warm Acupuncture Reduces Pain and Inflammation in Rats with Lumbar Disc Herniation Induced by Autologous Nucleus Pulposus Transplantation via Regulating p38MAPK/NF-κB Pathway
by: Feng Pan, et al.
Published: (2024)

Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages
by: Zhikun Li, et al.
Published: (2019)

Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways
by: Mengyuan Fang, et al.
Published: (2021)

Bergenin Monohydrate Attenuates Inflammatory Response via MAPK and NF-κB Pathways Against Klebsiella pneumonia Infection
by: Qihe Tang, et al.
Published: (2021)

Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway
by: Yun Yang, et al.
Published: (2018)