Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats

• Main Authors: Mohd Nazam Ansari (Author), Majid A. Ganaie (Author), Najeeb Ur Rehman (Author), Khalid M. Alharthy (Author), Tajdar H. Khan (Author), Faisal Imam (Author), Mushtaq A. Ansari (Author), Naif O. Al-Harbi (Author), Basit L. Jan (Author), Ishfaq A. Sheikh (Author), Abubaker M. Hamad (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels of cAMP via degradation. Hence, PDE inhibitors sensi...