Critical Role of Hepatic Cyp450s in the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice

• Main Authors: Cunzhi Yu (Author), Yu Li (Author), Mingxia Liu (Author), Man Gao (Author), Chenggang Li (Author), Hong Yan (Author), Chunzhu Li (Author), Lihan Sun (Author), Liying Mo (Author), Chunyong Wu (Author), Xinming Qi (Author), Jin Ren (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low solubility, tissue accumulation, and toxicity are chief obstacles to developing triptolide derivatives, so a better understanding of the pharmacokinetics and toxicity of triptolide derivatives will help with these limitations. To address this, we studied pharmacokinetics and toxicity of (5R)-5-h...