The B cell adaptor molecule Bam32 is critically important for optimal antibody response and resistance to Trypanosoma congolense infection in mice.

• Автори: Chukwunonso Onyilagha (Автор), Ping Jia (Автор), Nipun Jayachandran (Автор), Sen Hou (Автор), Ifeoma Okwor (Автор), Shiby Kuriakose (Автор), Aaron Marshall (Автор), Jude E Uzonna (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND:Bam32, a 32 kDa adaptor molecule, plays important role in B cell receptor signalling, T cell receptor signalling and antibody affinity maturation in germinal centres. Since antibodies against trypanosome variant surface glycoproteins (VSG) are critically important for control of parasitem...