Therapeutic implications of current Janus kinase inhibitors as anti-COVID agents: A review

• Hauptverfasser: Nem Kumar Jain (VerfasserIn), Mukul Tailang (VerfasserIn), Hemant Kumar Jain (VerfasserIn), Balakumar Chandrasekaran (VerfasserIn), Biswa Mohan Sahoo (VerfasserIn), Anandhalakshmi Subramanian (VerfasserIn), Neelaveni Thangavel (VerfasserIn), Afaf Aldahish (VerfasserIn), Kumarappan Chidambaram (VerfasserIn), M. Alagusundaram (VerfasserIn), Santosh Kumar (VerfasserIn), Palani Selvam (VerfasserIn)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been implicated in immunopathogenesis of COVID-19 infection under different stages such as viral entry, escaping innate immunity, replicatio...