Drug Discovery in the Field of β-Lactams: An Academic Perspective
β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis. A major mechanism of antibiotic resistance is the production of β-lactamase enzymes, which are capable of hydrolyzing...
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MDPI AG,
2024-01-01T00:00:00Z.
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