Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids

• Main Authors: Hongmei Yu (Author), Baoxi Zhang (Author), Meiju Liu (Author), Wenhui Xing (Author), Kun Hu (Author), Shiying Yang (Author), Guorong He (Author), Ningbo Gong (Author), Guanhua Du (Author), Yang Lu (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To modulate the physicochemical properties of fluconazole (FLZ), a multifunctional antifungal drug, the crystal engineering technique was employed. In this paper, five novel cocrystal hydrates of FLZ with a range of phenolic acids from the GRAS list, namely, 2,4-dihydroxybenzoic acid (24DHB), 3,4-di...