Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids

• Egile Nagusiak: Hongmei Yu (Egilea), Baoxi Zhang (Egilea), Meiju Liu (Egilea), Wenhui Xing (Egilea), Kun Hu (Egilea), Shiying Yang (Egilea), Guorong He (Egilea), Ningbo Gong (Egilea), Guanhua Du (Egilea), Yang Lu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

To modulate the physicochemical properties of fluconazole (FLZ), a multifunctional antifungal drug, the crystal engineering technique was employed. In this paper, five novel cocrystal hydrates of FLZ with a range of phenolic acids from the GRAS list, namely, 2,4-dihydroxybenzoic acid (24DHB), 3,4-di...