Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing

• मुख्य लेखकों: Fawaz Alasmari (लेखक), Mohammed S. Alasmari (लेखक), Hussa Mubarak Muwainea (लेखक), Hatun A. Alomar (लेखक), Abdullah F. Alasmari (लेखक), Sary Alsanea (लेखक), Aws Alshamsan (लेखक), Muhammad F. Rasool (लेखक), Faleh Alqahtani (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: Ceftriaxone is one of commonly prescribed beta-lactam antibiotics with several label and off-label clinical indications. A high fraction of administered dose of ceftriaxone is excreted renally in an unchanged form, and it may accumulate significantly in patients with impaired renal fun...