Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing

• Main Authors: Fawaz Alasmari (Author), Mohammed S. Alasmari (Author), Hussa Mubarak Muwainea (Author), Hatun A. Alomar (Author), Abdullah F. Alasmari (Author), Sary Alsanea (Author), Aws Alshamsan (Author), Muhammad F. Rasool (Author), Faleh Alqahtani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Ceftriaxone is one of commonly prescribed beta-lactam antibiotics with several label and off-label clinical indications. A high fraction of administered dose of ceftriaxone is excreted renally in an unchanged form, and it may accumulate significantly in patients with impaired renal fun...