Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

• Main Authors: Melissa R. Soto (Author), Mae M. Lewis (Author), Jasmim Leal (Author), Yuting Pan (Author), Rashmi P. Mohanty (Author), Arian Veyssi (Author), Esther Y. Maier (Author), Brittany J. Heiser (Author), Debadyuti Ghosh (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for local gene therapy. Here, we used phage display technology to select...