Dual sEH/COX-2 Inhibition Using PTUPB-A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity

• Main Authors: Wojciech K. Jankiewicz (Author), Scott D. Barnett (Author), Anna Stavniichuk (Author), Sung Hee Hwang (Author), Bruce D. Hammock (Author), Jawad B. Belayet (Author), A. H. Khan (Author), John D. Imig (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kidney injury from antiangiogenic chemotherapy is a significant clinical challenge, and we currently lack the ability to effectively treat it with pharmacological agents. Thus, we set out to investigate whether simultaneous soluble epoxide hydrolase (sEH) and cyclooxygenase-2 (COX-2) inhibition usin...