Reducing the Kidney Uptake of High Contrast CXCR4 PET Imaging Agents via Linker Modifications

• Main Authors: Daniel Kwon (Author), Zhengxing Zhang (Author), Jutta Zeisler (Author), Hsiou-Ting Kuo (Author), Kuo-Shyan Lin (Author), Francois Benard (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The C-X-C chemokine receptor 4 (CXCR4) is highly expressed in many subtypes of cancers, notably in several kidney-based malignancies. We synthesized, labeled, and assessed a series of radiotracers based on a previous high contrast PET imaging radiopharmaceutical [⁶⁸Ga...