Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

• Main Authors: Saira Khalique (Author), Stephen J Pettitt (Author), Ger Kelly (Author), Nina Tunariu (Author), Rachael Natrajan (Author), Susana Banerjee (Author), Christopher J Lord (Author)
• Format: Book
• Published: Wiley, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Development of resistance to platinum and poly(ADP‐ribose) polymerase inhibitors via secondary BRCA gene mutations that restore functional homologous recombination has been observed in a number of cancer types. Here we report a case of somatic BRCA2 mutation in a patient with high grade ser...