Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

• المؤلفون الرئيسيون: Saira Khalique (مؤلف), Stephen J Pettitt (مؤلف), Ger Kelly (مؤلف), Nina Tunariu (مؤلف), Rachael Natrajan (مؤلف), Susana Banerjee (مؤلف), Christopher J Lord (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2020-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Development of resistance to platinum and poly(ADP‐ribose) polymerase inhibitors via secondary BRCA gene mutations that restore functional homologous recombination has been observed in a number of cancer types. Here we report a case of somatic BRCA2 mutation in a patient with high grade ser...