Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER stress mediated cell apoptosis and pyroptosis

• Main Authors: Tao Wei (Author), Zhiwei Zheng (Author), Xiaoyan Wei (Author), Yugang Liu (Author), Wentao Li (Author), Bingqing Fang (Author), Di Yun (Author), Zhaojun Dong (Author), Baozhu Yi (Author), Wulan Li (Author), Xiaoping Wu (Author), Dezhi Chen (Author), Liping Chen (Author), Jianzhang Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curcumin is a natural medicine with a wide range of anti-tumour activities. However, due to β-diketone moiety, curcumin exhibits poor stability and pharmacokinetics which significantly limits its clinical applications. In this article, two types of dicarbonyl curcumin analogues with improved stabili...