Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

• Main Authors: Karah Nazor Friberg (Author), Gene Hung (Author), Ed Wancewicz (Author), Kurt Giles (Author), Chris Black (Author), Sue Freier (Author), Frank Bennett (Author), Stephen J DeArmond (Author), Yevgeniy Freyman (Author), Pierre Lessard (Author), Sina Ghaemmaghami (Author), Stanley B Prusiner (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mice deficient for the cellular prion protein (PrPC) do not develop prion disease; accordingly, gene-based strategies to diminish PrPC expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) targeted against mouse Prnp messenger RNA (mRNA) and ide...