4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling

• Main Authors: Lujun Xu (Author), Juan Cai (Author), Chenrui Li (Author), Ming Yang (Author), Tongyue Duan (Author), Qing Zhao (Author), Yiyun Xi (Author), Liya Sun (Author), Liyu He (Author), Chengyuan Tang (Author), Lin Sun (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure among hospitalized patients, and the inflammatory response is involved in this process. 4-octyl itaconate (4-OI) is a multi-target itaconate derivative with potent anti-inflammatory action. However, it...