Formulation, preparation and in vitro - in vivo evaluation of compression-coated tablets for the colonic-specific release of ketoprofen

• Main Authors: Dana Hales (Author), Dan Lucian Dumitrașcu (Author), Ioan Tomuță (Author), Corina Briciu (Author), Dana-Maria Muntean (Author), Lucia Ruxandra Tefas (Author), Sonia Iurian (Author), Rareș Iuliu Iovanov (Author), Marcela Achim (Author), Laurian Vlase (Author)
• Format: Book
• Published: Universidade de São Paulo, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT The aim of this study was to formulate and prepare compression-coated tablets for colonic release (CR-tablets), and to evaluate the bioavailability of ketoprofen following the administration of a single dose from mini-tablets with immediate release (IR-tablets) compared to CR-tablets. CR-ta...