Nafamostat Mesilate, a Potent Serine Protease Inhibitor, Inhibits Airway Eosinophilic Inflammation and Airway Epithelial Remodeling in a Murine Model of Allergic Asthma

• Main Authors: Masayuki Ishizaki (Author), Hiroyuki Tanaka (Author), Daisuke Kajiwara (Author), Tatsuyuki Toyohara (Author), Keiko Wakahara (Author), Naoki Inagaki (Author), Hiroichi Nagai (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma. Mice were sensitized to ovalbumin (OA) with alum and then exposed to 1% OA for 30 m...