MSCs-derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis

• Main Authors: Nehal M. Elsherbiny (Author), Mohamed S. Abdel-Maksoud (Author), Kousalya Prabahar (Author), Zuhair M. Mohammedsaleh (Author), Omnia A. M. Badr (Author), Arigue A. Dessouky (Author), Hoda A. Salem (Author), Omnia A. Refadah (Author), Ayman Samir Farid (Author), Ashraf A. Shamaa (Author), Nesrine Ebrahim (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chemotherapy detrimentally impacts fertility via depletion of follicular reserves in the ovaries leading to ovarian failure (OF) and development of estrogen deficiency-related complications. The currently proposed options to preserve fertility such as Oocyte or ovarian cortex cryopreservati...