Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

• المؤلفون الرئيسيون: Kelly L. Walton (مؤلف), Katharine E. Johnson (مؤلف), Craig A. Harrison (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis - mimicking an exaggerated "wound healing" response. Man...