Resveratrol inhibits Cdk5 activity through regulation of p35 expression

• Main Authors: Kulkarni Ashok B (Author), Iadarola Michael J (Author), Keller Jason (Author), Terse Anita (Author), Utreras Elias (Author)
• Format: Book
• Published: SAGE Publishing, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1. This re...