Repositioning of Cefuroxime as novel selective inhibitor of the thyroid hormone activating enzyme type 2 deiodinase

• Main Authors: Serena Sagliocchi (Author), Melania Murolo (Author), Annunziata Gaetana Cicatiello (Author), Caterina Miro (Author), Annarita Nappi (Author), Emery Di Cicco (Author), Sepehr Torabinejad (Author), Evelina La Civita (Author), Veronica Romano (Author), Daniela Terracciano (Author), Mariano Stornaiuolo (Author), Monica Dentice (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The iodothyronine deiodinases constitute a family of three selenoenzymes regulating the intracellular metabolism of Thyroid Hormones (THs, T4 and T3) and impacting on several physiological processes, including energy metabolism, development and cell differentiation. The type 1, 2 and 3 deiodinases (...