Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

• Main Authors: Daniel Hunziker (Author), Sabrina Reinehr (Author), Marina Palmhof (Author), Natalie Wagner (Author), Thomas Biniasch (Author), Gesa Stute (Author), Patrizio Mattei (Author), Petra Schmitz (Author), Patrick DiGiorgio (Author), Jérôme Hert (Author), Markus G. Rudolph (Author), Joerg Benz (Author), Martine Stihle (Author), Bernard Gsell (Author), Stephan Müller (Author), Rodolfo Gasser (Author), Nina Schonhoven (Author), Christoph Ullmer (Author), Stephanie C. Joachim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration. A link to the pathogenesis of glaucoma is suggested by an overactive ATX-LPA axis in aqueous humor samples of glaucoma patients. Analys...