Destabilization of spindle assembly checkpoint causes aneuploidy during meiosis II in murine post-ovulatory aged oocytes

• Главные авторы: Gaku SHIMOI (Автор), Masaru TOMITA (Автор), Marino KATAOKA (Автор), Yuichi KAMEYAMA (Автор)
• Формат: ‌
• Опубликовано: The Society for Reproduction and Development, 2018-11-01T00:00:00Z.
• Предметы: article
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Mammalian oocyte quality degrades over time after ovulation in vitro, which can cause fatal defects such as chromosomal aneuploidy. As various oocyte manipulations employed in assisted reproductive technology are time consuming, post-ovulatory aging is a serious problem to overcome in reproductive m...