Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

• Egile Nagusiak: Michela De Bellis (Egilea), Francesca Sanarica (Egilea), Alessia Carocci (Egilea), Giovanni Lentini (Egilea), Sabata Pierno (Egilea), Jean-François Rolland (Egilea), Diana Conte Camerino (Egilea), Annamaria De Luca (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Mexiletine (Mex) has been recently appointed as an orphan-drug in myotonic-syndromes, being a potent use-dependent blocker of skeletal-muscle sodium channels (NaV1.4). Available evidences about a potential anti-oxidant effect of Mex and its tetramethyl-pyrroline-derivatives in vivo, suggest the poss...