Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity

• Main Authors: Melissa Bersanelli (Author), Letizia Gnetti (Author), Francesco Paolo Pilato (Author), Elena Varotti (Author), Federico Quaini (Author), Nicoletta Campanini (Author), Elena Rapacchi (Author), Roberta Camisa (Author), Paolo Carbognani (Author), Enrico Maria Silini (Author), Michele Rusca (Author), Francesco Leonardi (Author), Umberto Maestroni (Author), Mimma Rizzo (Author), Matteo Brunelli (Author), Sebastiano Buti (Author), Luca Ampollini (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistance. This study aimed to assess the inter-tumoral, intra-tumoral, and intra-lesional heterogeneity of know...