Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors

• Main Authors: Casey L. Roberts (Author), Silvia S. Chen (Author), Angela C. Murchison (Author), Rebecca A. Ogle (Author), Michael P. Francis (Author), Roy C. Ogle (Author), Patrick C. Sachs (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for generating cells vastly different from the reprogrammed...