AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3

• Main Authors: Hua Ye (Author), Wenwen Yu (Author), Yunlei Li (Author), Xiaoqiong Bao (Author), Yangyang Ni (Author), Xiangxiang Chen (Author), Yangjie Sun (Author), Ali Chen (Author), Weilong Zhou (Author), Jifa Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected. The infiltration level of Mø and expression of M1 Mø, M2 Mø markers, and PD-L1 were assa...