Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry

• Hlavní autoři: Tian Xu (Autor), Fan Zhang (Autor), Daoyang Chen (Autor), Liangliang Sun (Autor), Daniela Tomazela (Autor), Laurence Fayadat-Dilman (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

ABSTRACTProduction of site-specific cysteine-engineered antibody-drug conjugates (ADCs) in mammalian cells may produce developability challenges, fragments, and heterogenous molecules, leading to potential product critical quality attributes in later development stages. Liquid phase chromatography w...